Simplicity and complexity in the cyanobacterial circadian clock mechanism
نویسندگان
چکیده
منابع مشابه
Frequency doubling in the cyanobacterial circadian clock
Organisms use circadian clocks to generate 24-h rhythms in gene expression. However, the clock can interact with other pathways to generate shorter period oscillations. It remains unclear how these different frequencies are generated. Here, we examine this problem by studying the coupling of the clock to the alternative sigma factor sigC in the cyanobacterium Synechococcus elongatus Using singl...
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متن کاملA cyanobacterial circadian timing mechanism.
Cyanobacteria such as Synechococcus elongatus PCC 7942 exhibit 24-h rhythms of gene expression that are controlled by an endogenous circadian clock that is mechanistically distinct from those described for diverse eukaryotes. Genetic and biochemical experiments over the past decade have identified key components of the circadian oscillator, input pathways that synchronize the clock with the dai...
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Richards J, Gumz ML. Mechanism of the circadian clock in physiology. Am J Physiol Regul Integr Comp Physiol 304: R1053–R1064, 2013. First published April 10, 2013; doi:10.1152/ajpregu.00066.2013.—It has been well established that the circadian clock plays a crucial role in the regulation of almost every physiological process. It also plays a critical role in pathophysiological states including ...
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Molecular genetic studies in the circadian model organism Synechococcus have revealed that the KaiC protein, the central component of the circadian clock in cyanobacteria, is involved in activation and repression of its own gene transcription. During 24 hours, KaiC hexamers run through different phospho-states during daytime. So far, it has remained unclear which phospho-state of KaiC promotes ...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2010
ISSN: 0959-437X
DOI: 10.1016/j.gde.2010.09.002